Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms

Impairment of health after overcoming the acute phase COVID-19 is being observed more and frequently. Here different symptoms neurological and/or cardiological origin have been reported. With symptoms, which are very similar to ones reported but not caused by SARS-CoV-2, occurrence functionally active autoantibodies (fAABs) targeting G-protein coupled receptors (GPCR-fAABs) has discussed be involved. We, therefore investigated, whether GPCR-fAABs detectable in 31 patients suffering from Long-COVID-19 recovery disease. The spectrum was mostly (29/31 patients), including post-COVID-19 fatigue, alopecia, attention deficit, tremor others. Combined cardiovascular disorders were 17 patients. Two recovered free follow-up symptoms. All former had between 2 7 that acted as receptor agonists. Some those activate their target cause a positive chronotropic effect neonatal rat cardiomyocytes, read-out test system for detection (bioassay GPCR-fAAB detection). Other GPCR-fAABs, opposite, negative on cells. identified blood Long-COVID targeted ?2-adrenoceptor (?2-fAAB), ?1-adrenoceptor (?1-fAAB), angiotensin II AT1-receptor (AT1-fAAB), nociceptin—like opioid (NOC-fAAB). muscarinic M2-receptor (M2-fAAB), MAS-receptor (MAS-fAAB), ETA-receptor (ETA-fAAB). It analysed extracellular loops autoantibodies.